Fig. 5

Created with BioRender.com. The bidirectional arrow represents the interaction between CD112R and its ligand. CD112R engages with its ligand, and the phosphorylated Y²³³ residue of the ITIM-like motif recruits SHIP-1 and SHP1/2 to mediate signal transduction, leading to a decrease in T cell cytotoxicity. Additionally, CD112R potentially represents a new coinhibitory receptor that suppresses T cell receptor-mediated NFAT activation