Table 2 Clinical trials in promising cancer target of PVR like receptors

NCT04099277

DNAM-1

LY3435151

2

aI/b1

Solid Tumor, Triple-negative Breast Cancer, Gastric Adenocarcinoma, Head and Neck Squamous Cell Carcinoma, Cervical Carcinoma, High Grade Serous Ovarian Carcinoma, Undifferentiated Pleomorphic Sarcoma, Leiomyosarcoma

Terminated

May 5, 2020

NCT04656535

TIGIT

AB154

46

0/I

Glioblastoma

Not yet recruiting

Jul, 2023

NCT03628677

TIGIT

AB154

66

I

Solid Tumor, Unspecified, Adult

Recruiting

Nov 10, 2021

NCT04262856

TIGIT

AB154

150

II

Non Small Cell Lung Cancer, Nonsquamous Non Small Cell Lung Cancer, Squamous Non Small Cell Lung Cancer, Lung Cance

Recruiting

Jun 23, 2022

NCT04736173

TIGIT

AB154

625

III

Non Small Cell Lung Cancer, Nonsquamous Non Small Cell Lung Cancer, Squamous Non-small-cell Lung Cancer, Lung Cancer

Recruiting

Jun 30, 2026

NCT03945253

TIGIT

ASP8374

6

I

Advanced Solid Tumors

Completed

Jun 12, 2020

NCT03260322

TIGIT

ASP8374

169

I

Advanced Solid Tumors

Active, not recruiting

Mar, 2022

NCT04693234

TIGIT

BGB-A1217

167

II

Cervical Cancer

Not yet recruiting

Mar 31, 2023

NCT04732494

TIGIT

BGB-A1217

280

II

Esophageal Squamous Cell Carcinoma

Recruiting

Mar, 2024

NCT04047862

TIGIT

BGB-A1217

234

I

Locally Advanced, Metastatic Solid Tumors

Recruiting

Aug, 2023

NCT04746924

TIGIT

BGB-A1217

605

III

Non-small Cell Lung Cancer

Not yet recruiting

Mar, 2025

NCT04150965

TIGIT

BMS-986207

104

I/II

Multiple Myeloma, Relapsed Refractory Multiple Myeloma

Recruiting

Mar 30, 2022

NCT04354246

TIGIT

COM902

45

I

Advanced Cancer, Ovarian Cancer; Lung Cancer, Colon Cancer; Plasma Cell Neoplasm, Breast Cancer

Recruiting

Sep 30, 2022

NCT04353830

TIGIT

IBI939

270

Ia/Ib

Advanced Malignancies

Recruiting

Dec 31, 2023

NCT04672369

TIGIT

IBI939

36

I

Advanced Lung Cancer

Not yet recruiting

Oct 9, 2024

NCT04672356

TIGIT

IBI939

20

I

Advanced Lung Cancer

Recruiting

Nov 9, 2024

NCT04457778

TIGIT

M6223

35

I

Metastatic Solid Tumors

Recruiting

Sep 14, 2022

NCT04305054

TIGIT

MK-7684

315

I/II

Melanoma

Recruiting

Apr 3, 2030

NCT04305041

TIGIT

MK-7684

200

I/II

Melanoma

Recruiting

Apr 3, 2030

NCT04303169

TIGIT

MK-7684

65

I/II

Melanoma

Recruiting

Apr 3, 2030

NCT04761198

TIGIT

MPH313

125

I/II

Solid Tumor, Adult Advanced Solid Tumor, Metastatic Solid Tumor

Recruiting

Jun 30, 2023

NCT04543617

TIGIT

MTIG7192A

750

III

Esophageal Squamous Cell Carcinoma

Recruiting

Dec 26, 2025

NCT04256421

TIGIT

MTIG7192A

470

III

Small Cell Lung Cancer

Recruiting

Sep 29, 2023

NCT04294810

TIGIT

MTIG7192A

560

III

Non-Small Cell Lung Cancer

Recruiting

Feb 21, 2025

NCT03708224

TIGIT

MTIG7192A

55

II

Cancer, Carcinoma, Squamous Cell Carcinoma, Head and Neck Cancer

Recruiting

Nov 30, 2025

NCT03563716

TIGIT

MTIG7192A

135

II

Non-small Cell Lung Cancer

Active, not recruiting

Oct 30, 2021

NCT03281369

TIGIT

MTIG7192A

410

I/II

Gastric Adenocarcinoma or Gastroesophageal Junction Adenocarcinoma or Esophageal Carcinoma

Recruiting

Feb 11, 2023

NCT03119428

TIGIT

OMP-31 M32

33

I

Locally Advanced Cancer, Metastatic Cancer

Terminated

May 15, 2019

NCT04254107

TIGIT

SGN-TGT

231

I

Non-small Cell Lung Cancer, Gastric Carcinoma, Gastroesophageal Junction Carcinoma, Classical Hodgkin Lymphoma, Diffuse Large B-cell Lymphoma, Peripheral T-cell Lymphoma, Cutaneous Melanoma, Head and Neck Squamous Cell Carcinoma; Bladder Cancer, Ovarian Cancer, Triple Negative Breast Cancer

Recruiting

Mar 31, 2023

NCT04570839

CD112R

COM701

100

I/II

Endometrial Neoplasms, Ovarian Cancer, solid Tumor

Recruiting

Dec, 2023

NCT03667716

CD112R

COM701

140

I

Advanced Cancer, Ovarian Cancer, Breast Cancer, Lung Cancer, Endometrial Cancer, Ovarian Neoplasm, Triple Negative Breast Cancer, Lung Neoplasm, Neoplasm Malignant, Colo-rectal Cancer

Recruiting

Dec, 2021