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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: Apatinib triggers autophagic and apoptotic cell death via VEGFR2/STAT3/PD-L1 and ROS/Nrf2/p62 signaling in lung cancer

Fig. 1

The inhibitory effects of apatinib on the proliferation of NSCLC cells. a MTT assay of cell viability in A549 and H1299 cells after indicated apatinib treatment. The data are presented as mean ± SD (n = 6). *p < 0.05, **p < 0.01 vs. control. b Cell morphology of A549 and H1299 cells after apatinib treatment for 48 h. Scar bar = 100 μm. c EdU staining (EdU, green; DAPI, blue) of A549 and H1299 cells after apatinib treatment for 48 h and quantitation of the percentage of EdU-positive cells. Scar bar = 100 μm. The data are presented as mean ± SD (n = 3). **p < 0.01 vs. control. d AO/EB staining of A549 and H1299 cells after apatinib treatment for 24 h and quantitation of the percentage of cell death. The live cells with normal nuclei appeared green and the dead cells with condensed or fragmented chromatin in the nuclei appeared red. Scar bar = 100 μm. The data are presented as mean ± SD (n = 3). **p < 0.01 vs. control

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