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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: Apatinib triggers autophagic and apoptotic cell death via VEGFR2/STAT3/PD-L1 and ROS/Nrf2/p62 signaling in lung cancer

Fig. 7

Apatinib inhibited the growth of NSCLC cells in vivo. a Images of the xenograft tumors of the control and apatinib treatment group. b and c Tumor volume and tumor weight were measured. **p < 0.01 vs. control. The data are presented as mean ± SD (n = 5). **p < 0.01 vs. control. d Body weights of mice were recorded every 3 days after indicated treatment. The data are presented as mean ± SD (n = 5). e ELISA assay of VEGFR2 expression in tumors. The data are presented as mean ± SD (n = 5). **p < 0.01 vs. control. f and g Western blot analysis of Cyclin D1, Cleaved Caspase 3, Nrf2, p62, and LC3 expressions in tumors. h-j H&E staining of tumors and immunohistochemical staining of Cyclin D1, Cleaved Caspase 3, Nrf2, p62, LC3, E-cadherin, Vimentin, VEGFR2, p-STAT3, c-Myc, and PD-L1 expression in the tumors

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