Fig. 5

A Mass spectrometry images of PTX distribution in BxPC3 tumour tissues after PEGPH20 or vehicle pre-treatment; three tumours were analysed for each group. One representative section of three analysed for each tumour is shown; B The features describing drug distribution (mean, CV%, LZE-Large-Zone Emphasis, HGZE-High Grey-level Zone Emphasis, IV-Intensity Variability, GLNn-normalised Grey-Level Non-uniformity and DHI-Drug Homogeneity Index) and C tumour concentrations of PTX 4 h after the last treatment. D Representative HA staining images in the BxPC3 tumour, in PTX and PTX + PEGPH20 treated animals. E Tumour growth of BxPC3 bearing mice (n = 8) after treatment with PEGPH20 and PTX singly or in combination