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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: SIRT1 regulates the phosphorylation and degradation of P27 by deacetylating CDK2 to promote T-cell acute lymphoblastic leukemia progression

Fig. 1

High SIRT1 expression in T-ALL. a RNA-seq expression profiles of SIRT1 in the T-ALL, B-ALL and normal samples from public database. b Immunoblots of SIRT1 in leukemia cell lines. c SIRT1 mRNA expression in leukemia cell lines. d Schematic representation of murine T-ALL model. e Kaplan-Meier survival curves of mice harboring MSCV-ICN1 and MSCV-Vector HSPCs (n = 5 per group). f SIRT1 mRNA expression in T-ALL mouse model and control group. g-h Immunoblots and relative quantification expression of SIRT1 in T-ALL mouse model and control group (n = 3)

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