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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: SIRT1 regulates the phosphorylation and degradation of P27 by deacetylating CDK2 to promote T-cell acute lymphoblastic leukemia progression

Fig. 5

SIRT1 decreases p27 protein levels. a Western blot analysis of proteins associated with cell cycle entry in SIRT1 knockdown MOLT-4 (left panel) and CCRF-CEM (right panel). b Relative mRNA expression of MYC, SKP2, SIRT1, HES1 and p27 in SIRT1 knockdown MOLT-4 (top panel) and CCRF-CEM (bottom panel). c-d Western blotting for p27 following CHX treatment of SIRT1 knockdown or control MOLT-4 and CCRF-CEM (left panel). The right panel showed results of densitometry quantitation (n = 3). e Western blotting for p27 expression in SIRT1 WT and KO T-ALL. f Relative mRNA expression of SIRT1-exon4, p27, MYC, SKP2, HES1 in SIRT1 WT and KO T-ALL

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