Fig. 8
From: Circ-GALNT16 restrains colorectal cancer progression by enhancing the SUMOylation of hnRNPK
Circ-GALNT16 regulates Serpine1 through the SUMOylation of hnRNPK and p53. a, b. The mRNA and protein level of Serpine1 was detected in circ-GALNT16 knockdown and overexpression cells while hnRNPK was silenced. c. The expression of Serpine1 was detected in circ-GALNT16 knockdown cells while SENP2 was silenced. d. The expression of Serpine1 in circ-GALNT16 silencing cells was detected with the Pifithrin-α (10µM) treatment. e, f. HnRNPK and p53 chromatin immunoprecipitation were performed to measure the hnRNPK and p53 enrichment at the promoter region(s) of Serpine1 in DLD-1 and RKO. All data are presented as the means ± SD of three independent experiments. nsp > 0.05, **p < 0.01