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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Cyclin G2 reverses immunosuppressive tumor microenvironment and potentiates PD-1 blockade in glioma

Fig. 5

Cyclin G2 potentiated PD-1 blockade in glioma mice model. a Schematic depicting experimental setup. C57BL/6 mice were subcutaneously (s.c.) injected with GL261-OE or GL261-EV cells and treated with α-PD-1 or isotype intraperitoneally (i.p.). Gross tumors(b), tumor growth curves(c), tumor weight(d) at the endpoint and overall survival(e) are shown. n = 5. scale bar, 1 cm. f-k Results of flow cytometry showing the frequency of Treg, IFN-γ + CD4 + and IFN-γ + CD8 + T cells in tumors of each group. n = 3 for each group. l-o Levels of IFN-γ, TNF-α, TGF-β and IL-10 in tumors of each group as determined by ELISA. Data are presented as the mean ± s.d. *p < 0.05, **p < 0.01 and ***p < 0.001; ns, not significant

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