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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: CIRP promotes the progression of non-small cell lung cancer through activation of Wnt/β-catenin signaling via CTNNB1

Fig. 4

CIRP Promotes the Tumorigenesis of NSCLC Cells. (A) Representative photographs showing the effect of silencing CIRP on the colony formation of A549 and H460 cells. The clone numbers are shown in histograms representing the means ± SD from three independent experiments (**, P < 0.01). (B) Representative photographs showing the effect of CIRP overexpression on the colony formation of H1299 and H1650 cells. The clone numbers are shown in histograms representing the means ± SD from three independent experiments (*, P < 0.05 and **, P < 0.01). (C) A549 cells were subcutaneously inoculated into BALB/c nude mice after infection with Le-scrambled or Le-shCIRP at an MOI of 10 (n = 9 for each group). Twenty-eight days later tumors were harvested. (D) The weight of established tumors was measured and is shown in a scatter plot. (E) Immunohistochemical analysis of CIRP expression was performed on these xenografts. Representative images are shown (magnification × 200)

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