Fig. 1From: SHOX2 cooperates with STAT3 to promote breast cancer metastasis through the transcriptional activation of WASF3SHOX2 in TCGA breast cancer patient samples. (a) Higher SHOX2 expression corresponds with significantly worse progression free survival and disease-specific survival. (b) SHOX2 expression is differentially overexpressed in estrogen receptor-negative (ER−) breast tumors when compared to estrogen receptor-positive (ER+) tumors. **** p < 0.0001. (c, d) Breast tumors deemed “SHOX2-high” tumors (z-score > 1.25) differentially overexpressed transcripts preferentially involved in the epithelial-to-mesenchymal transitioning. (e) SHOX2 expression significantly correlates with the MSigDB Gene Hallmark dataset “EPITHELIAL_MESENCHYMAL_TRANSITION”Back to article page