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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: SHOX2 cooperates with STAT3 to promote breast cancer metastasis through the transcriptional activation of WASF3

Fig. 4

STAT3 cooperates with SHOX2 to promote WASF3 gene transcription. (a) The accumulation of SHOX2 on the WASF3 promoter was determined by ChIP-QPCR assays in MDA-MB-231 and T47D cells. (b) The effect of 20 ng/ml IL6 on the expression of WASF3 and SHOX2 in T47D cells. (c) The effect of SHOX2 overexpression on WASF3 and STAT3 expression and phosphorylation in T47D cells. (d) The effect of STAT3 knockdown (shSTAT3-1 and shSTAT3-2) on WASF3 expression in SHOX2 overexpressing T47D cells. (e) The effect of 50 µM S3I-201 on WASF3 expression in SHOX2 overexpressing T47D cells. *p < 0.05, **p < 0.01

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