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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: Chemotherapy-triggered changes in stromal compartment drive tumor invasiveness and progression of breast cancer

Fig. 1

Chemotherapy-exposed MSC. (A) Chemosensitivity of three different isolates of MSC to doxorubicin (DOX, 50 ng/ml) and paclitaxel (PAC, 4 ng/ml) after 48-hour treatment. (B) Morphology of MSC exposed to chemotherapeutics. (C) Cytokine determination using the Proteome Profiler Human XL Cytokine Array Kit revealed that DOX exposure was associated with increased secretion of SDF-1α, IL-32, THBS1, DPPIV and uPAR in DOX-MSC compared to unexposed MSC. PAC exposure resulted in decreased production of CXCL5, endoglin, Dkk-1 and increased production of IL-32. (D) Exposure-induced differences in Dkk-1 levels were validated in various MSC isolates. Dunnett T3 test was used for statistical evaluation. Statistically significant results are highlighted with asterisks at p < 0.05 (*), p < 0.01 (**)

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