Fig. 5

ALKBH5-HOXA10 loop steadily promotes cell proliferation and resistance to cisplatin. (a and b) CCK8 and EdU proliferation assays show that using specific siRNAs to respectively knock down HOXA10 or ALKBH5 expression in EOC cells with ALKBH5 or HOXA10 expression could significantly suppress cancer cell proliferation. (c and d) HOXA10 or ALKBH5 knockdown rescues resistance to cisplatin and DDR in EOC cells with ALKBH5- HOXA10 loop overexpression