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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: ZNF507 affects TGF-β signaling via TGFBR1 and MAP3K8 activation in the progression of prostate cancer to an aggressive state

Fig. 1

Increased ZNF507 expression in various PC databases and PC tissues. A ZNF507 expression data in normal (n = 42) and PC tissues (n = 277) as retrieved from the GENT2 database. B ZNF507 expression data in normal (n = 13) and PC tissues (n = 44) as retrieved from the EMBL-EBI database (Liu et al.). C The survival rate of PC patients compared by low-ZNF507 (n = 246) expressed and high-ZNF507 (n = 246) expressed groups from the GEPIA database. TPM; Transcripts per million, HR; hazard ratio. The median value was used for the group classification. p = 0.82, HR = 0.86. D Relative ZNF507 expression in non-recurrent (primary) PC (n = 37) and recurrent PC tissues (n = 45) as retrieved from the EMBL-EBI database (Sun et al.). E ZNF507 expression in the normal and Gleason graded PC tissues as retrieved from the EMBL-EBI database (Liu et al.) (NA, n = 13; grade 6, n = 13; grade 7, n = 16; grade 8, n = 10; grade 8+, n = 5; *, compared to NA group; #, compared to grade 6 group; §, compared to grade 7 group). F ZNF507 expression in normal (n = 28), primary PC (n = 59), and mCRPC (n = 34) as retrieved from the GEO database (*, compared to normal group; #, compared to primary PC group). G Genomic alteration frequency of ZNF507 in NEPC, mCRPC, and PA as retrieved from the cBioPortal database. H Average of the relative ZNF507 expression from benign hyperplasia (n = 6) and Gleason score 8 patient tissues (n = 15) specimens compared to its related β-actin intensity. I Representative western blot data showing ZNF507 expression from benign hyperplasia and Gleason score over 8 PC patient tissues. J Relative mRNA expression of ZNF507 from benign hyperplasia (n = 16) and Gleason score 8 PC tissues from patients (n = 14). K Representative IHC staining of ZNF507 in benign hyperplasia and Gleason grade 4 and 5 PC tumor tissues (Scale bar = 100 μm). The data are presented as the Means ± SD from three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001 versus normal control

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