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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: circHMGCS1–016 reshapes immune environment by sponging miR-1236-3p to regulate CD73 and GAL-8 expression in intrahepatic cholangiocarcinoma

Fig. 1

Elevated circHMGCS1–016 in ICC tissues and its clinical implication for ICC patients. A. The heatmap of circRNA sequencing showed the top up- and down-regulation of circRNAs between ICC and adjacent nontumor tissues (left). Volcano plot showed the differentially expressed circRNAs and circHMGCS1–016 was among the top 3 up-regulated ones (right);B. Schematic illustration of circHMGCS1–016; C. RT-PCR amplified the circHMGCS1–016. Electrophoresis showed molecular weight of circHMGCS1–016 and the sequence of back splice site was also presented; D. The differential expression of circHMGCS1–016 in ICC tissues and adjacent nontumor tissues of 40 patients as indicated. Data are representative of 3 independent tests; E. In situ hybridization analysis showed that ICC samples had higher expression of circHMGCS1–016 than that in matched peri-tumor samples (Bar = 200 μm). The scatter diagram showed the expression of circHMGCS1–016 in ICC and nontumorous tissues (*** p < 0.001); F. Kaplan-Meier analysis of OS and recurrence in 135 ICC patients according to circHMGCS1–016 expression; G. Univariate and multivariate analyses of factors associated with OS and recurrence

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