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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: RNA m6A demethylase FTO-mediated epigenetic up-regulation of LINC00022 promotes tumorigenesis in esophageal squamous cell carcinoma

Fig. 1

Up-regulated LINC00022 predicts poor prognosis of ESCC patients. (A) LINC00022 was one of the most up-regulated LncRNAs in two independent ESCC cohorts from GSE75241 and TCGA. The overall differentially expressed LncRNAs (DELncRNAs) in GSE75241 (15 normal tissues vs. 15 tumor tissues) dataset were shown as a heat map (A, upper left). The top-200 up-regulated DELncRNAs in TCGA-ESCC (11 normal tissues vs. 81 tumor tissues) dataset were shown as a heat map (A, upper right). The Venn diagram in the middle shows that LINC00022 is the only overlapped LncRNA in the two discovery datasets. Box plots from both GSE75241 and TCGA-ESCC datasets indicate the significant up-regulation of LINC00022 in ESCC tumor samples as compared to normal samples (A, bottom). (B) The elevation of LINC00022 was validated by additional three ESCC cohorts, including our in-house cohort (a, 44 pairs of ESCC tissues), GEPIA cohort (b, 286 normal tissues vs. 182 tumor tissues) and CRN cohort (c, 10 normal tissues vs. 39 tumor tissues). (C-D) The diagnostic values of LINC00022 in our cohort and GSE75241 cohort were evaluated by ROC. (E) The prognostic significance of LINC00022 in GEPIA cohort was determined by the Kaplan-Meier method. Increased LINC00022 expression predicted an unfavorable patient OS. (F) The expression of LINC00022 in Het-1A, TE1, KYSE70, KYSE150 and KYSE450 was examined by qRT-PCR, *p < 0.05; **p < 0.01

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