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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Modelling hypersensitivity to trastuzumab defines biomarkers of response in HER2 positive breast cancer

Fig. 3

Genomic characterization of trastuzumab-resistant and trastuzumab-hypersensitive cell lines. A Volcano plots shows DEGs in BTRH and BTSH versus the parental cell line BT474 and DEGs between BTRH and BTSH cells identified by transcriptomic analysis. Genes are considered differentially expressed if fold change ≥2 and p-value ≤0.05. DEGs are represented in green, if downregulated or red, if upregulated; genes in white are out of the cutt-off. B Principal component analysis of variance between signal data. Triplicates of each cell line are represented in the same color. C Venn diagrams show the number of “inverse amount” DEGs overlapped between BTRH and BTSH versus the parental BT474. Genes upregulated in BTRH versus BT474 were compared to genes downregulated in BTSH versus BT474 and vice versa. D The bar chart shows fold change values of 29 “inverse amount” genes in BTRH and BT474 versus the parental cell line BT474

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