Skip to main content
Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: Embedding similarities between embryos and circulating tumor cells: fundamentals of abortifacients used for cancer metastasis chemoprevention

Fig. 7

Effects of oral metapristone and mifepristone on embryo implantation to mouse uterine horns of normal female mice and CTC adhesion/invasion to lungs of BALB/C female mice. Photos (A) and effects (B) of mifepristone and metapristone (both 5 mg/kg given once on Day 4 of pregnancy) on the number of embryos implanted in the mouse uterine horns; (C) immunohistochemical staining showed reduction of MMP-2/9 expressed in mouse endometrium after drug treatments. Photos (D) and effects (E) of mifepristone and metapristone on lung tumor nodules induced by 4T1 mouse breast cancer cells inoculated (iv) into mouse circulation; (F) immunohistochemical staining showed the expressions of MMP-2/9 in mouse embryo and mouse lungs were reduced by metapristone and mifepristone. n = 8; *, P < 0.05; **, P < 0.01, compared with the control

Back to article page