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Fig. 8 | Journal of Experimental & Clinical Cancer Research

Fig. 8

From: MEST promotes lung cancer invasion and metastasis by interacting with VCP to activate NF-κB signaling

Fig. 8

The expression of MEST and VCP in metastatic cancer and a schematic diagram of the action mechanism of MEST. A Two representative IHC images of MEST and VCP expression in primary lung cancer tissues and in corresponding metastatic tumor tissues. Differences in MEST and VCP expression scores between lung cancer and metastatic tumor tissues are shown (n = 30). Scale bar, 50 μm. B Working model of MEST on promotion of cancer metastasis. MEST is upregulated in highly invasive lung cancer cells, it interacts with VCP and increases VCP to capture IκBα for degradation, leading to the nuclear translocation of p65 to activate the NF-κB pathway for cancer metastasis. In addition, MEST can induce IκBα phosphorylation via the STAT3/IKK pathway, mediating NF-κB signaling activation at multiple levels

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