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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: Tumor cell-derived SPON2 promotes M2-polarized tumor-associated macrophage infiltration and cancer progression by activating PYK2 in CRC

Fig. 1

SPON2 is positively correlated with M2-TAM infiltration and poor prognosis in CRC patients. a The expression of SPON2 in the M2-low (n = 125), M2-medium (n = 208), and M2-high (n = 49) groups of TCGA-COAD and READ patients. Student’s t test, **** p < 0.0001. b The correlation between mRNA levels of SPON2 and M2-TAM markers (CD68, CD206 and CD163) of TCGA-COAD and READ patients. Two-tailed Pearson test. n = 458. c Representative double immunohistochemistry images of SPON2 and CD68 expression and representative immunohistochemistry images of CD163 in the same CRC tissue microarray (n = 67) (red: SPON2, brown: CD68, CD163). Scale bar, 100 μm. d Pearson's chi-squared test was used to analyze the correlation between SPON2 expression and CD163+ TAM infiltration in CRC patients (n = 67). χ2 = 25.540, p < 0.0001. e Kaplan–Meier analyses of the overall survival and disease-free survival of CRC patients with low versus high expression of SPON2 (n = 67)

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