Fig. 7

Proposed model. a Model of SPON2 biological function. SPON2 promotes transendothelial migration of monocytes and induces polarization of TAMs toward the M2 phenotype by stimulating gene expression of IL10, CCL2 and and CSF1 in CRC cells to maintain the infiltration of M2 tumor-associated macrophages. b Schematic representations of the role of the SPON2/integrin β1/PYK2 axis in the recruitment of TAMs. SPON2 activates PYK2 in macrophages and monocytes by binding integrin β1. Activated PYK2 recruits more zyxin to promote the formation of focal adhesion complexes that are involved in stress fiber maintenance of migrating cells