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Table 2 Univariate and multivariable analyses of OS and DFS in HCC patients

From: DNMT1-induced miR-378a-3p silencing promotes angiogenesis via the NF-κB signaling pathway by targeting TRAF1 in hepatocellular carcinoma

Variable

OS

DFS

Univariate analysis

Multivariable analysis

Univariate analysis

Multivariable analysis

P > |z|

P > |z|

HR(95%CI)

P > |z|

P > |z|

HR(95%CI)

miR-378a-3p expression

 Low (n = 54) vs. high (n = 54)

< 0.001

0.003

0.414(0.232-0.736)

0.001

0.010

0.454(0.249-0.828)

Gender

 Male (n = 75) vs. female (n = 33)

0.944

  

0.737

  

Age (years)

  ≤ 60 (n = 83) vs. > 60 (n = 25)

0.518

  

0.837

  

Grade of differentiation

 Low (n = 56) vs. middle-high (n = 52)

0.330

  

0.444

  

Tumor diameter (cm)

  ≤ 5 (n = 50) vs. > 5 (n = 58)

0.588

  

0.294

  

Liver function (Child-Pugh stage)

 A (n = 92) vs. B or C (n = 16)

0.901

  

0.980

  

Hepatocirrhosis

 Absent (n = 31) vs. present (n = 77)

0.874

  

0.698

  

Hepatitis B virus

 Absent (n = 43) vs. present (n = 65)

0.189

  

0.692

  

Tumor thrombus

 Absent (n = 65) vs. present (n = 43)

0.079

  

0.052

  

AFP (ng/ml)

  ≤ 20 (n = 53) vs. > 20 (n = 55)

0.264

  

0.973

  

BCLC stage

 I (n = 41) vs. II, III, or IV (n = 67)

0.194

  

0.149

  

Envelope

 Absent (n = 52) vs. present (n = 56)

0.142

  

0.946

  

Tumor satellite

 Absent (n = 63) vs. present (n = 45)

0.146

  

0.411

  

MVD

 High (n = 59) vs. Low (n = 49)

< 0.001

0.018

2.048(1.129-3.715)

0.001

0.022

2.036(1.106-3.746)