Fig. 4

Heat map showing overlap of (A) Mechanism of action (B) Serious AEs and/or Grade 3 or above AEs for screened drugs (A) *chemotherapy has also been shown in some studies to downregulate PD-L1 and PD-L2 expression on DCs and induce cytotoxic activity of CTLs and NK cells, B * Early reports from clinical studies evaluating TIGIT did not report any dose limiting toxicities, except a case of grade 2 diarrhea. **Reduced blood cell count is used as a broad category of AEs and includes direct suppression of bone marrow generation of blood cells as well as indirect reductions in blood cell counts resulting in neutropenia, anemia, decreased lymphocyte count and thrombocytopenia. *** SAEs sorted in the ‘Others’ category are sometimes unique for the drug and cannot be combined as a single category. Early phase 1 studies for anti-Tim-3, anti-Lag-3, AB928 and Reolysin did not report serious adverse events but evidence from studies in larger cohort is not available and are represented accordingly (grey). Data includes rare events and may include AEs that are probably not related to study. ARF, acute renal failure; ALF, acute liver failure