Fig. 2

Alterations of the immune system caused by Chronic Lymphocytic Leukemia (CLL) B-cells. BTLA, B- and T-lymphocyte attenuator; CD, cluster of differentiation; CLL, chronic lymphocytic leukemia; CTLA-4, cytotoxic T-lymphocyte-associated protein 4; IFN-γ, interferon gamma; LN, lymph node; MDSC, myeloid-derived suppressor cells; NK, natural killer; TAM, tumor-associated macrophages; PD-1, program cell death protein 1; TCR, T-cell receptor; Th, T helper; TNF-α, tumor necrosis factor alpha; T-reg, regulatory T-cell; X, impairment