Fig. 2

L1CAM is both necessary and sufficient for ovarian cancer tumorigenicity. (A) NSG mice were injected subcutaneously with a low number of either L1CAM-knockdown or control SKOV-3 cells (500 cells/site; n = 10) and tumor growth was monitored. (B) NSG mice were injected subcutaneously with a low number of either L1CAM-transduced or control Ov90 cells (250 cells/site; n = 8). (C) Tumor take is expressed as the percentage of mice with tumor at the three time points indicated. Data refer to the mice shown in (A) and (B) and are expressed as means ± SEM. Comparisons between experimental groups were done with two-way ANOVA with multiple comparison; *p < 0.05, **p < 0.01, ***p < 0.001