Fig. 5
From: Arachidonic acid drives adaptive responses to chemotherapy-induced stress in malignant mesothelioma
Pemetrexed-instigated release of AA activated NFkB. A. Protein levels of IKB detected by ELISA in MPM cells, pre-treated or not with a cPLA2 inhibitor (AVX001, 3 micromol/L for 90 min), and treated as indicated. Statistics: * p < 0.05 ** p < 0.01. ns = not significant (p > 0.05). B. Representative box plots showing the nuclear content of the NFkB subunit p65 bound to a synthetic NFkB responsive element and detected by ELISA in cell extracts of HP1 (left panel), NCI-H2373 (middle panel) and MSTO-211H (right panel). Statistics: * p < 0.05; ns = not significant (p > 0.05)