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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: VEGF-A/VEGFR-1 signalling and chemotherapy-induced neuropathic pain: therapeutic potential of a novel anti-VEGFR-1 monoclonal antibody

Fig. 4

Cellular localization of VEGF-A and VEGFR-1 in the spinal cord of naïve mice. VEGF-A immunoreactivity was analysed in the spinal cord dorsal horn of naïve mice. Colocalization with GFAP-positive astrocytes (a, n = 9), Iba-1 positive microglia (b, n = 8) and NeuN-positive neurons (c, n = 7) was evaluated and quantified (d). Quantitative analysis (e) of immunofluorescence co-staining of VEGFR-1 in the dorsal horn with GFAP (f, n = 7) or NeuN (g, n = 8) positive cells. Scale bar: 100 μm. Each value represents the mean ± SEM. §§P < 0.01 vs VEGF-A + Iba-1 and VEGF-A + NeuN. ^^P < 0.01 vs VEGFR-1 + GFAP. The analysis of variance was performed by Oone-way ANOVA. A Bonferroni’s significant difference procedure was used as post-hoc comparison

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