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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: VEGF-A/VEGFR-1 signalling and chemotherapy-induced neuropathic pain: therapeutic potential of a novel anti-VEGFR-1 monoclonal antibody

Fig. 5

VEGF-A expression in endothelial and astrocytic cells of murine spinal cord. (a) VEGF-A immunoreactivity was analysed in the spinal cord dorsal horn of naïve mice in comparison to RECA-1-positive endothelial cells and GFAP-positive astrocytes; arrows indicate the presence of VEGF-A in astrocytes; scale bar: 100 μm. (b and c) Deconvolved confocal z-stacks shown as maximum intensity projection. Arrows indicate points of interest. (b) Representative GFAP and VEGF-A z-stack. (c) Representative VEGF-A and aquaporin-4 z-stack. Table). Colocalization parameters are given as mean ± SEM (n = 8), PCC = Pearson’s Correlation Coefficient; M1 = Mander’s M1; M2 = Mander’s M2; Li′s ICQ = Li′s Intensity Correlation Quotient. Colocalization graphs are shown in Fig. S4

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