Fig. 6

VEGF-A is increased in spinal astrocytes of mice with oxaliplatin-induced neuropathy. (a) Representative images and quantitative analysis of mean VEGF-A fluorescence intensity in the dorsal horn of oxaliplatin-treated mice in comparison to control animals (vehicle, n = 13). (b-d) Colocalization analysis of VEGF-A and GFAP in control (b) and oxaliplatin-treated mice (c). Quantitative analysis of colocalization area (d) (vehicle, n = 13; oxaliplatin, n = 12). Scale bar: 100 μm; insert: 50 μm. Each value represents the mean ± SEM. *P < 0.05 vs vehicle group. The analysis of variance was performed by one-way ANOVA. A Bonferroni’s significant difference procedure was used as post-hoc comparison