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Table 1 Selected factors/biomarkers of response and resistance to ICIs

From: Serological assessment of collagen fragments and tumor fibrosis may guide immune checkpoint inhibitor therapy

Response Resistance
Tumor mutational burden (TMB) Myeloid-derived-suppressor cells (MDSCs)
Neoantigen expression Tumor-associated macrophages (TAMs)
High levels of microsatellite instability (MSI-H) Regulatory T cells (Tregs)
Deficient mismatch repair (dMMR) Extracellular matrix (ECM)
Tumor-infiltrating lymphocytes Collagen
Inflammation gene signature Cancer-associated fibroblasts (CAFs)
PD-L1 expression Transforming growth factor-beta (TGF-β)
LAG-3 expression  
Host factors (Microbiome)