Fig. 4
From: High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer
Mechanisms of action described for high-dose VitC in combination with anti-cancer agents in pre-clinical studies. Summary of anti-cancer VitC effects described in vitro and in vivo studies for a total of 45 combinations in the last 5 years (2016–2021). Detailed mechanism of actions per anti-cancer agent are described below. Colour legend corresponds to each mechanism described