Fig. 8

Expression levels of TGFB1/2 and ZEB1 and their correlations with SGO1-AS1 expression in GC tissues. a-c. Relative expression levels of TGFB1, TGFB2 and ZEB1 in 92 paired GC and normal tissues from Cohort 2 were quantified by qRT-PCR. The pie charts show the proportions of samples in the downregulation (blue), upregulation (red) and no change (yellow) categories. d-f. The expression levels of TGFB1, TGFB2 and ZEB1 in GCs according to their clinical stage and status of lymph node or distant metastasis. g. SGO1-AS1 expression was inversely correlated with TGFB1, TGFB2 and ZEB1 expression, while ZEB1 expression was positively correlated with TGFB1/2 expression in the GC specimens. Error bars indicate SDs. *P < 0.05, **P < 0.01, ***P < 0.001. h. Schematic illustration of the TGFβ/ZEB1/SGO1-AS1 signaling pathway. TGFβ downregulates SGO1-AS1 by inducing ZEB1. SGO1-AS1 inactivates TGFβ signaling by promoting TGFB mRNA decay