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Table 3 Tools used for assessing OIPN

From: Targeting strategies for oxaliplatin-induced peripheral neuropathy: clinical syndrome, molecular basis, and drug development

OIPN Tools References
Current tools used for the clinical diagnosis of OIPN National Cancer Institute-Common Toxicity Criteria (NCI-CTC) [23]
Total Neuropathy Score clinical version (TNSc) [24]
Modified Inflammatory Neuropathy Cause and Treatment (INCAT) group sensory sum score (mISS) [25]
European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 [27]
CIPN (chemotherapy induced peripheral neuropathy) 20 quality-of-life measures [26]
Skin biopsy and quantified intraepidermal nerve fiber density [28, 29]
LDI technology [22]
Surface electromyography recording [30]
Comments for the ideal CIPN assessment tools Specific to CIPN; validated in different types of chemotherapy; easy for patients to understand and complete; can be used in postal questionnaires as well as face to face; performs consistently in different settings; requires minimal training in use and scoring; sensitive to change; detects CIPN early; and reliable with minimal interrater variability [2]
  1. CIPN Chemotherapy-induced peripheral neuropathy, LDI Laser Doppler imager, OIPN Oxaliplatin-induced peripheral neuropathy