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Table 6 A summary of ASCO recommendations for preventative and treatment therapies for CIPN

From: Targeting strategies for oxaliplatin-induced peripheral neuropathy: clinical syndrome, molecular basis, and drug development

Strength of recommendation Preventative therapies Treatment therapies
Strong recommendation against Acetyl-L-carnitine None
Moderate recommendation against Acetylcysteine, Amifostine, Amitriptyline, Calcium and magnesium, Cannabinoids, Calmangafodipir, Carbamazepine/oxcarbazepine, L-carnosine, DDTC, Gabapentin/pregabalin, Glutamate/glutamine, GSH, GJG–Kampo medicine, Metformin, Minocycline, Nimodipine, Omega 3, Org 2766, Retinoic acid, rhuLIF, Venlafaxine, Vitamin B, Vitamin E None
Inconclusive date: No recommendation Acupuncture, Compression therapy, Cryotherapy, Exercise, GM1, Acupuncture, Exercise, Gabapentin/pregabalin, BAK, Oral cannabinoids, Tricyclic antidepressants, Scrambler therapy
Moderate recommendation for None Duloxetine
Strong recommendation for None None
  1. BAK Topical amitriptyline, ketamine, 6 baclofen, CIPN Chemotherapy-induced peripheral neuropathy, DDTC Diethyldithiocarbamate, GJG Goshajinkigan, GM1 Monosialotetrahexosylganglioside, GSH Glutathione, rhuLIF Recombinant human leukemia inhibitory factor