Fig. 1

lnc-RP11-536 K7.3 was highly expressed in oxaliplatin-resistant organoids of CC patients. A Circos plot displaying the distribution and expression of lncRNAs on human chromosomes. The outermost layer was a chromosome map of the human genome. The inner circles from outside to inside were corresponded to distribution and expression of detected lncRNAs on the chromosomes, distribution and expression of significantly expressed lncRNAs, and predicted mRNAs sponged by significantly expressed lncRNAs, respectively. B Differentially expressed lncRNAs between 3 oxaliplatin-resistant and 3 -sensitive organoids. C Differential expression of lnc-RP11-536 K7.3 in 22 oxaliplatin-resistant and 22 -sensitive organoids of CC patients detected by qPCR. The experiment was repeated 3 times. D Fluorescence in situ hybridization (FISH) assay of lnc-RP11-536 K7.3 in 22 oxaliplatin-resistant and 22 -sensitive organoids of CC patients. E Kaplan-Meier plot of disease free survival (DFS) according to lnc-RP11-536 K7.3 expression. Data were obtained from Shanghai Cancer Center. F Kaplan-Meier plot of overall survival (OS) according to lnc-RP11-536 K7.3 expression. Data were obtained from Shanghai Cancer Center. G qRT-PCR assay was used to detect the efficacy of lnc-RP11-536 K7.3 knockout in oxaliplatin-resistant organoids. The experiment was repeated 3 times. H Gene ontology of mass spectrum analysis in oxaliplatin-resistant and -sensitive colon cancer organoids. I Pathway examination of mass spectrum analysis in oxaliplatin-resistant and -sensitive colon cancer organoids