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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Lnc-RP11-536 K7.3/SOX2/HIF-1α signaling axis regulates oxaliplatin resistance in patient-derived colorectal cancer organoids

Fig. 6

Knockout of lnc-RP11-536 K7.3 inhibits progression of CC cells and sensitizes response to oxaliplatin in vivo. A Schematic illustration of subcutaneous injection of the organoids and cells. B Representative images of nude mice bearing tumors generated by knockout of lnc-RP11-536 K7.3 and chemo-resistant CC organoids with or without oxaliplatin treatment. C Xenograft tumor growth in mice (**P < 0.01). D Average tumor weight of nude mice (**P < 0.01). E Average SUVmax value of PET-CT in nude mice bearing tumors. F-G qRT-PCR assay was used to detect the expressions of ALDOA and GLUT1. The experiment was repeated 3 times. H-I FISH and immunofluorescence assay were performed on the xenograft tumors of RP11-536 K7.3-KO and control groups with oxaliplatin treatment. J A zebrafish model treated with or without oxaliplatin. K qRT-PCR assay was employed to detect the expression of VEGFA in a zebrafish model (**P < 0.01). The experiment was repeated 3 times

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