Skip to main content
Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: ZIP10 drives osteosarcoma proliferation and chemoresistance through ITGA10-mediated activation of the PI3K/AKT pathway

Fig. 6

ZIP10 correlates positively with p-CREB, ITGA10 and p-AKT in osteosarcoma patients. a Representative cases from 52 OS specimens (without chemotherapy) were analyzed by IHC staining for Ki67, ZIP10, p-CREB, ITGA10 and p-AKT. Scale bar, 20 μm. b-f The expression of ZIP10 and p-CREB (b), ZIP10 and ITGA10 (c), ZIP10 and p-AKT (d), ITGA10 and p-CREB (e), and ITGA10 and p-AKT (f) was analyzed in 52 OS specimens. The relative proportions of protein expression are illustrated as a pie chart. g-i The percentage of samples displaying low or high ZIP10 expression compared to the expression levels of p-CREB (g), ITGA10 (h) and p-AKT (i). j, k The percentage of specimens displaying low or high ITGA10 expression compared to the expression levels of p-CREB (j) and p-AKT (k). l-p Scatterplot showing the positive correlation between ZIP10 and p-CREB (l), ZIP10 and ITGA10 (m), ZIP10 and p-AKT (n), ITGA10 and p-CREB (o), ITGA10 and p-AKT (p) expression in OS patients

Back to article page