Fig. 7

Proposed model of ZIP10 regulation of proliferation and chemoresistance in osteosarcoma. ZIP10 expression is elevated in OS, which might be a result of Zn deficiency and chemotherapy. ZIP10 increases Zn uptake and activates CREB and its binding to the ITGA10 promotor and thus promotes ITGA10 expression in OS cells. ITGA10 is an important membrane-anchored protein that confers OS cell proliferation and chemoresistance through activation of the PI3K/AKT signaling pathway. Targeting ZIP10 in OS might increase chemotherapy sensitization in OS