Fig. 7

Clinical significance of TMPRSS4, SNAI2, TWIST1, and SOX2 expression in prostate cancer patients. A Scatter plots of TMPRSS4 mRNA expression (x-axis) vs. SOX2, PROM1 (CD133), SNAI2, or ALDH1A1 mRNA expression (y-axis) from prostate adenocarcinoma data (TCGA, Firehose Legacy). B Scatter plots of TMPRSS4 mRNA expression (x-axis) vs. SOX2 or TWIST1 mRNA expression (y-axis) from prostate adenocarcinoma data (MSKCC, Cancer Cell 2010). A scatter plot of TWIST1 mRNA expression (x-axis) vs. SOX2 mRNA expression (y-axis) is also shown. C Correlation analysis between expression levels of SOX2 and several EMT-inducing transcription factors (n = 1156) from CCLE data (Broad, 2019). D A scatter plot of SNAI2 mRNA expression (x-axis) vs. TWIST1 mRNA expression (y-axis) from CCLE data (Broad, 2019). Correlations were statistically analyzed using the Spearman test. Equations were automatically generated using the cBioPortal webpage tool