Fig. 8

Proposed working model for the suppressive effect of cDOPEY2 on the cisplatin resistance of ESCC. cDOPEY2 originates from exons 20-24 of the DOPEY2 gene by a back-splicing event. CPEB4 promotes the translational activation of Mcl-1 by enhancing the cytoplasmic polyadenylation of its mRNA by binding to its CPEs. cDOPEY2 maintains cisplatin resistance of ESCC cells by facilitating the TRIM25-mediated ubiquitination and proteasomal degradation of CPEB4 by forming a cDOPEY2/CPEB4/TRIM25 ternary complex