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Table 2 Antitumor effects of SAHA and ST0001 against the human synovial sarcoma CME-1

From: Upregulation of ERK-EGR1-heparanase axis by HDAC inhibitors provides targets for rational therapeutic intervention in synovial sarcoma

Drug

Dose (mg/kg/day)

Schedule

TVI%a (day 49)

SAHA

100

qdx5/w x4w

42

ST0001

60

2qdx5/w x4w

14

SAHA + ST0001

100

60

qdx5/w x4w

2qdx5/w x4w

66*

  1. *P < 0.05 vs control
  2. a Tumor Volume Inhibition percent at the end of experiment