Table 5 ISWI-contaning complexes in cancer and their functions

SNF2L-NURF complex-Circ-DONSON

GC cell lines (BGC-823, AGS, MGC-803, MKN74, HGC-27 and SGC-7901)

Activating SOX4 transcription, which leads to the proliferation, migration and invasion of GC cells

SNF2L-NURF complex-LncRNA DLEU1

Human colorectal cell lines (HCT8 and SW480 cell)

Initiating KPNA3 expression and promoting cell proliferation, migration and invasion

SNF2L-NURF complex-LncHOXA10

Primary liver TICs

Activating HOXA10 transcription to promote the self-renewal of liver tumor initiating cells (TICs)

SNF2L-NURF complex-LncGata6

Mouse intestinal stem cells

Promoting Ehf transcription, which subsequently induces Lgr4/5 expression and activation of Wnt signaling in intestinal stem cells (ISCs)

SNF2L-NURF complex-WASH

Mouse long term-hematopoietic stem cells

WASH assists the NURF complex in the c-Myc promoter and enhances gene transcription, which maintains the differentiation potential of long-term hematopoietic stem cells (LT-HSCs) to mature blood lineages

SNF2L-NURF complex-ZIC2

Primary liver CSCs and Hep3B cell lines

Initiating OCT4 activation to maintain the self-renewal of liver CSCs

SNF2H-CTCF complex

MEL and OCI-M2 cells

Being recruited to the enhancer of PU.1 gene and block gene expression

RSF1-cyclin E1

Renal epithelial cells

Contributing to neoplastic transformation in the presence of TP53 mutations

SNF2H-RSF1-NF-κB

Ovarian cancer cells lines (SKOV3, OVCAR3, and A2780)

Activating NF-κB–dependent gene expression, contributing to the development of chemoresistance

SNF2H-ACF1-CHRAC15-CHRAC17-KU70/80

U2OS/TRE/I-SceI-19 cells

Playing important roles on double-strand breaks repair

WSTF-RUVBL2- INTS3- RUNX2

Breast, prostate, and bone cancer cells lines (Saos2, U2OS, MDA-MB-231 and PC3)

Mounting an integrated response to DNA damage through supporting histone displacement, DNA unwinding, and stabilization of single-stranded DNA

WSTF-NRG3

Colon cancer cells line (SW48)

Activating oncogenic pathways of the surrounding normal colon cells through mediating cell–cell communication

TIP5-EZH2

Prostate cancer cell line (PC3)

Participating in epigenetic silencing of AOX1, FBN1, FHL2 and HOMER2 genes

BPTF-c-Myc

Pre-neoplastic pancreatic acinar cells

Increasing c-MYC recruitment to target genes and regulating chromatin accessibility at promoters, thus increasing target genes’ transcription

BPTF-P50-NF-κB

Lung cancer cell lines (A549 and NCI-H460)

Increasing COX-2 expression by binding to COX-2 promoter region, promoting tumor cell growth

BPTF-WDR5

Bladder cancer cell line (LD611)

Promoting the expression of tumorigenic genes

RBBP7-NKX6.1

Cervical cancer cell line (HeLa)

Serving as a repressor to bind to vimentin promoter, thus suppressing its transcription

RBBP7-HNF1B

Prostate cancer cell line (DU145)

Repressing SLUG expression and EMT phenotype

RBBP7/4-MTA2/Mi-2/HDAC1/2 -TWIST

Human and mouse breast cancer cells (MDA-MB-435 and 4 T1)

Suppressing E-cadherin transcription, inducing EMT program

RBBP4–BCL11A

Breast cancer cell line (SUM149)

The recruitment of RBBP4-BCL11A complexes to BCL11A-targeted genes decreases aldehyde dehydrogenase-positive breast cancer stem cells (BCSCs) and their mammosphere formation capacity

RBBP4-ARMC12

Neuroblastoma cell lines (SH-SY5Y, BE(2)-C and IMR32)

Facilitating the formation of PRC2 in neuroblastoma, resulting in transcriptional repression of tumor suppressive genes

RBBP4-CBP/p300

Glioblastoma cell line (T98)

Promoting DNA repair genes expression, which influences the survival against temozolomide (TMZ)therapy

RBBP4-LncRNA LCPAT1

Breast cancer cell lines (MCF-7 and MDA-MB-231)

Activating MFAP2 transcription and promoting breast cancer progression