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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Focal adhesion kinase inhibitor TAE226 combined with Sorafenib slows down hepatocellular carcinoma by multiple epigenetic effects

Fig. 4

Effect of TAE226 > SOR on HCC growth in mouse xenograft model. A Scheme of the experimental design. Imaging analysis was performed at different times (I). B Quantitative analysis and representative pictures of in vivo bioluminescence imaging analysed before administration of compounds (day 0) and during treatments at days 14, 21, 28 or 35. Luminescent signals are expressed as mean ± SD of total flux of photons/sec/cm2/steradian (p/s/cm2/sr). Data were analysed by ANOVA test. (**p < 0.01; n = 6). Representative images of immunofluorescence for PCNA (in red) (C) and pTyr397FAK (in green) (D) in mouse xenograft models after treatments. The nuclei are revealed by specific DAPI staining, displayed in blue. 40X Magnification

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