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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: Focal adhesion kinase inhibitor TAE226 combined with Sorafenib slows down hepatocellular carcinoma by multiple epigenetic effects

Fig. 7

Effect of TAE226 > SOR on nuclear amount of pTyr397FAK. A Representative images of immunofluorescence for pTyr397FAK (in green) into the nuclei and at focal adhesions after treatments, in HepG2 and Huh7 cells. The nuclei are revealed by specific Hoechst staining (in blue). 40X Magnification. Content of pTyr397FAK into the nuclei (B) and at focal adhesions (C) in HepG2 and Huh7 cells, quantified by using the Operetta CLS in confocal mode. 40X Magnification. Values are the mean of arbitrary units ± SD of at least three independent experiments. Data were analysed by 2-tailed Student’s t test. *p < 0.05; **p < 0.01; ***p < 0.001 vs. NT. D Representative images of immunofluorescence for pTyr397FAK (in green) in xenograft models of HCC. 60X Magnification

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