Fig. 1From: Fibroblast growth factor receptor fusions in cancer: opportunities and challengesFGF–FGFR-HS system. A 18 functional mammalian FGFs sorted into six subfamilies. Each founding members are colored in orange. B Left: paracrine FGFs bind to the D2-D3 domains of FGFRs and HS to form 2:2:2 FGF-FGFR-HS complex (PDB: 1FQ9). Right: Endocrine FGF-FGFR-Klotho complex PDB ID: 5 W21). Alternatively-spliced D3 domain of FGFR is highlighted in purpleBack to article page