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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Fibroblast growth factor receptor fusions in cancer: opportunities and challenges

Fig. 3

FGFR autoinhibition mechanisms. A Schematic representations of FGFR autoinhibition modes consisting of acid box regulation, molecular brake, DFG latch, and the repulsion between enzyme and substrate kinases B overall view of the asymmetric FGFR kinase A-loop transphosphorylation complex (PDB: 6PNX). Enzyme- and substrate-acting FGFR kinases are colored in green, blue and wheat, respectively. C FGFR3 K659 and R669 form enzyme-substrate electrostatic clash. Sequence alignment of the kinase domains of FGFR1–4 shows the conservation of autoinhibition mechanism. D Hydrogen bonding pattern of the autoinhibitory molecular brake in FGFR1 (left, PDB ID: 1fgk) and disengaged brake (right, PDB ID: 3gqi). The dashed lines denote hydrogen bonds

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