Fig. 5From: Fibroblast growth factor receptor fusions in cancer: opportunities and challengesFGFR inhibitors. A Chemical structures of selected FGFR inhibitors and PROTAC. The hinge binding region and FGFR hydrophobic pocket binding group are highlighted. B Structures of second- and third-generation drug-FGFR complexes, including erdafitinib (5ew8), infigratinib (3tt0), debio-1347 (5b7v), and TAS120 (6mzw) in complex with FGFR1 kinase domainBack to article page