Fig. 1From: BH3-mimetics: recent developments in cancer therapyThe BH- and helical- domain composition of selected Bcl-2 family pro-apoptotic (red boxes), anti-apoptotic (blue boxes) and BH3-only (green boxes) members. The amino acid sequences of the human BH3-domains from BAX and BAK are highlighted (top left), below which are shown the amino acid sequences of the alpha helices 2–5 from the human Bcl-2 protein. For each of the proteins, the transmembrane domain is highlighted in orange and BH1–4 domains are respectively highlighted in blue, black, red and green for the relevant proteinsBack to article page