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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: BH3-mimetics: recent developments in cancer therapy

Fig. 1

The BH- and helical- domain composition of selected Bcl-2 family pro-apoptotic (red boxes), anti-apoptotic (blue boxes) and BH3-only (green boxes) members. The amino acid sequences of the human BH3-domains from BAX and BAK are highlighted (top left), below which are shown the amino acid sequences of the alpha helices 2–5 from the human Bcl-2 protein. For each of the proteins, the transmembrane domain is highlighted in orange and BH1–4 domains are respectively highlighted in blue, black, red and green for the relevant proteins

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