Table 1 The Bcl-2 protein family members can be sub-grouped into pro-apoptotic (Pro-), anti-apoptotic (Anti-) and sensitizer (Sen-) members, which originate from distinct genetic loci and encode proteins of varying amino-acid (aa) length and molecular weight (in kilodaltons, kDa). Each member can be localized in the cytoplasm (C), mitochondria (M), endoplasmic reticulum (ER) or the nucleus (N) and can be regulated through its interaction with other protein family members through protein-protein interactions
Protein | Apoptosis | Gene | Size (kDa) | Location | Protein Partners |
|---|---|---|---|---|---|
BAX | Pro- | 19q13.33 | 192aa (21.18) | C, M, N, ER | BAK, Bcl-2,Bcl-xL,Mcl1, BID, BIM, NOXA |
BAK | Pro- | 6p21.31 | 211aa (23.40) | M | BAX, Bcl-2, Bcl-xL, Mcl1, BID |
Bcl-2 | Anti- | 18q21.33 | 239aa (26.00) | C, M, N, ER | BAX, BAK, Bcl-xL, BID, BIM, BAD, PUMA, NOXA |
Bcl-xL | Anti- | 20q11.21 | 233aa (26.04) | M, C | BAX, BAK, Bcl-2, BID, BIM BAD, PUMA |
Mcl1 | Anti- | 1q21.20 | 350aa (37.33) | C, M, N | BAX, BAK, BID, BIM, PUMA, NOXA |
BID | Pro-/Sen- | 22q11.21 | 195aa (21.99) | C, M | BAX, BAK, Bcl-2, Bcl-xL, Mcl1 |
BIM | Pro-/Sen- | 2q13.00 | 198aa (22.17) | C, M | BAX, Bcl-2, Bcl-xL, Mcl1, |
BAD | Pro-/Sen- | 11q13.10 | 168aa (18.39) | C, M | Bcl-2, Bcl-xL |
PUMA | Pro-/Sen- | 19q13.32 | 193aa (20.53) | M | Bcl-2, Bcl-xL, Mcl1, |
NOXA | Pro-/Sen- | 9q34.30 | 476aa (50.93) | C, M, N | BAX, Bcl-2, Mcl1, |
SMAC | Pro-/Sen- | 12q24.31 | 239aa (27.13) | C, M | xIAP1 |