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Table 1 The Bcl-2 protein family members can be sub-grouped into pro-apoptotic (Pro-), anti-apoptotic (Anti-) and sensitizer (Sen-) members, which originate from distinct genetic loci and encode proteins of varying amino-acid (aa) length and molecular weight (in kilodaltons, kDa). Each member can be localized in the cytoplasm (C), mitochondria (M), endoplasmic reticulum (ER) or the nucleus (N) and can be regulated through its interaction with other protein family members through protein-protein interactions

From: BH3-mimetics: recent developments in cancer therapy

Protein Apoptosis Gene Size (kDa) Location Protein Partners
BAX Pro- 19q13.33 192aa (21.18) C, M, N, ER BAK, Bcl-2,Bcl-xL,Mcl1, BID, BIM, NOXA
BAK Pro- 6p21.31 211aa (23.40) M BAX, Bcl-2, Bcl-xL, Mcl1, BID
Bcl-2 Anti- 18q21.33 239aa (26.00) C, M, N, ER BAX, BAK, Bcl-xL, BID, BIM, BAD, PUMA, NOXA
Bcl-xL Anti- 20q11.21 233aa (26.04) M, C BAX, BAK, Bcl-2, BID, BIM BAD, PUMA
Mcl1 Anti- 1q21.20 350aa (37.33) C, M, N BAX, BAK, BID, BIM, PUMA, NOXA
BID Pro-/Sen- 22q11.21 195aa (21.99) C, M BAX, BAK, Bcl-2, Bcl-xL, Mcl1
BIM Pro-/Sen- 2q13.00 198aa (22.17) C, M BAX, Bcl-2, Bcl-xL, Mcl1,
BAD Pro-/Sen- 11q13.10 168aa (18.39) C, M Bcl-2, Bcl-xL
PUMA Pro-/Sen- 19q13.32 193aa (20.53) M Bcl-2, Bcl-xL, Mcl1,
NOXA Pro-/Sen- 9q34.30 476aa (50.93) C, M, N BAX, Bcl-2, Mcl1,
SMAC Pro-/Sen- 12q24.31 239aa (27.13) C, M xIAP1